MPMA has a central office in Littleton, CO. Its governing structure includes a board of directors and numerous committees and affiliates. Staff includes an executive director and an office assistant. This group oversees the services that MPMA provides. An annual fall conference is attended by nearly 300 professionals each year. The conference provides opportunities for all levels of professionals in training, networking, and information exchange at a relatively inexpensive cost. Over 700 individuals, institutions and businesses annually support MPMA by paying membership dues. A bi-monthly newsletter and a discount purchasing cooperative program are available to members.
MPMA is one of six regional associations in the United States that works in conjunction with the American Association of Museums. The associations form the Council of Regions and meet twice yearly to advise AAM on issues relating to museums in the particular regions.